Intuitively, an isotropic distribution is rotationally invariant. That is, it is the same in all directions when viewed from the origin. For instance, a normal is isotropic, because the variance is the same in all directions.
Mathematically, we say a distribution is isotropic if for all orthogonal matrices ,
in distribution, where . The opposite of isotropy is an anisotropic distribution.
A characterization of isotropy comes from Vershynin, Lemma 3.2.3: is isotropic iff for all fixed .